L1-Specific Protection from Tumor Challenge Elicited by HPV16 Virus-like Particles

Gene expression patterns induced by HPV-16 L1 virus-like particles in leukocytes from vaccine recipients.

Human papillomavirus (HPV) virus-like particle (VLP) vaccines were recently licensed. Although neutralizing Ab titers are thought to be the main effectors of protection against infection, early predictors of long-term efficacy are not yet defined and a comprehensive understanding of innate and adaptive immune responses to vaccination is still lacking. Here, microarrays were used to compare the ...

Cervical secretory immunoglobulin A to human papillomavirus type 16 (HPV16) from HPV16-infected women inhibit HPV16 virus-like particles-induced hemagglutination of mouse red blood cells.

Secretory immunoglobulin A (sIgA) antibodies are the first line of defence at the genital mucosa, and are thought to hinder viral infections by binding to conformational epitopes on the viral capsid. To investigate if cervical sIgA binds to conformational epitopes of the Human papillomavirus type 16 (HPV16), cervical mucus samples from 109 HPV16-infected patients were examined in a HPV16 virus-...

Isolation of virus like particles from fecal material obtained from diarrheal calves

Disseminated Cutaneous Rhinosporidiosis: a Tumor like Lesion with Therapeutic Challenge

Rhinosporidiosis is a granulomatous disorder caused by Rhinosporidium seeberi, an aquatic parasite. It spreads through contaminated water and soil. It frequently involves the nasal cavity and nasopharynx. Disseminated or systemic lesions are rare. A 56 year old man presented with multiple tumor like lesions all over the body in our cancer institute in April 2012. Fine needle aspiration cyto...

Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model.

Papillomavirus-like particles (VLPs) are a promising prophylactic vaccine candidate to prevent human papillomavirus (HPV) infections and associated epithelial neoplasia. However, they are unlikely to have therapeutic effects because the virion capsid proteins are not detected in the proliferating cells of the infected epithelia or in cervical carcinomas. To increase the number of viral antigen ...